Here follows a list in alphabetical order explaining abbreviations and expressions used on our website.


AIE stands for anion exchange chromatography and is an HPLC method that separates molecules on net charge.


ASR stands for Analytic Specific Reagent and is a pharmaceutical classification made by US FDA. It could be explained as an active ingredient of an in-house test.


Contamination is the presence of a minor and unwanted constituent in a material. In our case contamination of a product with another oligonucleotide could be devastating as it may influence the products ability to target detection. In order to prevent contamination of our products we handle each product to be used for IVD/ASR purposes separately in every production step and never expose the products to an uncontrolled environment. As a result of our careful procedures we can give a non-contamination guarantee for this type of products.


FDA stands for  Food and Drug Administration, and is an agency of the United States Department of Health and Human Services, responsible for protecting and promoting public health through regulation and supervision of food safety, pharmaceuticals, medical devices etc.


GMP stands for Good Manufacturing Practice, and is a part of a quality system covering the manufacture and testing of active pharmaceutical ingredients, diagnostics, pharmaceutical products and medical devices. GMP is guidelines that outline the aspects of production and testing that can impact the quality of a product.


HPLC stands for High Performance Liquid Chromatography and is a form of column chromatography used frequently in biochemistry and analytical chemistry to separate, identify and quantify compounds.


IVD stands for In Vitro Diagnostics, which are medical devices intended to perform diagnoses from assays in a test tube, or more generally in a controlled environment outside a living organism.


ISO is a family of standards for quality management system. These standards are maintained by ISO (international Organization for Standardization) and are administrated by accreditation and certification bodies. We are certified according to ISO-9001:2008 and ISO-13485:2003.


MGB stands for Minor Groove Binder and is a crescent shaped molecule that fits into the minor groove of the DNA double helix structure, stabilizing the binding between the probe and the target. Probes with an attached MGB molecule hybridize more strongly to their complementary sequences than regular DNA probes and display increased melting temperature (15-30 ºC) allowing for the use of shorter, yet highly specific, probes.


MSDS stands for Material Safety Data Sheet, and is a form containing data regarding the properties of a particular substance. No MSDS is needed for our products within the European Union, as in vitro diagnostic medical devices are extempted from the classification requirements.


Oligonucleotide is a short nucleic acid polymer.


RP stands for Reversed phase and is an HPLC method that separates molecules on hydrophobicity.

RQ probe

Reporter-Quencher (RQ) probe is a dual labeled fluorescent probe. The fluorescent reporter dye is attached to the 5’-end of the probe and the quencher dye could be attached either internally or to the 3’-end of the probe. The quencher has the ability to absorb the fluorescence emitted from the reporter dye. The excess energy gained by the quencher in this way, is then emitted at wavelengths corresponding to the emission spectra of the quencher or as heat if a dark quencher is used. During the elongation phase in the PCR reaction the active polymerase starts to degrade the probe, separating the reporter dye from the quencher. In order to prevent the RQ probe from acting like a primer during the elongation phase, the 3´-end of the probe must be phosphorylated. As the elongation proceeds, the reporter dye and the quencher dye drift apart, leaving the quencher unable to absorb the fluorescence emitted from the reporter dye, resulting in a detectable fluorescence signal from the reporter dye. The use of MGB technology is covered by international patents owned by Epoch Biosciences. Organisations wishing to incorporate MGB into a diagnostic product or service, require a license and should contact Epoch Biosciences.


The SCORPIONS® oligonucleotide is a bi-functional molecule containing a PCR primer covalently linked to a probe. The use of SCORPIONS® technology is covered by US6,326,145 and foreign patents owned and controlled by QIAGEN Manchester Ltd. Organizations wishing to incorporate SCORPIONS® technology into diagnostic product or commercial service, require a license and should contact QIAGEN Corporate Business Development at bd@qiagen.com.


UPLC stands for Ultra Performance Liquid Chromatography, and is a new form of HPLC with increased speed, sensitivity and resolution.